The 193rd Infantry Brigade was constituted on June 24, 1921, in the Organized Reserves as Headquarters and Headquarters Company, 193rd Infantry Brigade, and assigned to the 97th Division. It was organized in June 1922 at Augusta, Maine. In February 1942, the brigade was converted and redesignated as the 97th Reconnaissance Troop, 97th Division, and ordered into active military service in February 1943 at Camp Swift, Texas. During World War II, the unit participated in the Central Europe campaign, contributing to the elimination of the Ruhr pocket and advancing into Czechoslovakia before inactivating in March 1946 in Japan.
In response to Cold War tensions, the brigade was reactivated on August 8, 1962, in the Panama Canal Zone, assuming the ground defense of the canal. It played a significant role in Operation Just Cause in 1989, which led to the ousting of Panamanian leader Manuel Noriega. Following the implementation of the Panama Canal Treaties, the brigade was inactivated on October 14, 1994. On January 31, 2007, the 193rd Infantry Brigade was transferred to the United States Army Training and Doctrine Command and reactivated at Fort Jackson, South Carolina, where it currently focuses on training and developing soldiers to build readiness for the U.S. Army.